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ì¼ë°˜ì 으로, 당해 업계ì—ì„œ 통ìƒì˜ 지ì‹ì„ 가진 ìžëŠ” ì „ìž ë„는 기, ì „ìž ì£¼ëŠ” 기, ë˜ëŠ” ìƒê¸° ê¸°ë“¤ì˜ ì¡°í•©ì„ í¬í•¨í•˜ë„ë¡ ê¸°ë¥¼ 변경하는 ê²ƒì— ì˜í•´ ìƒì²´í™˜ì› ê¸°ì˜ ì‚°í™” í™˜ì› ë°˜ì‘ ì „ìœ„ë¥¼ "ì¡°ì •"í• ìˆ˜ 있다. 예를 들어, 나ì´íŠ¸ë¡œí‹°ì˜¤íŽœ, 나ì´íŠ¸ë¡œí‘¸ëž€, ë° ë‚˜ì´íŠ¸ë¡œí‹°ì•„졸기는 바람ì§í•œ ì‚°í™” í™˜ì› ë°˜ì‘ ì „ìœ„ë¥¼ 달성하기 위해 메틸, 메톡시, ë˜ëŠ” 아민기를 í¬í•¨í•˜ì§€ë§Œ ì œí•œë˜ëŠ” ê²ƒì€ ì•„ë‹Œ 하나 ì´ìƒì˜ ì „ìž ì£¼ëŠ” 기로 치환ë 수 있다.
여기서 ê¸°ìž¬ëœ ë°©ë²•ì— ë”°ë¥´ë©´, í¬ìŠ¤í¬ë¼ë¯¸ë°ì´íŠ¸ 알킬화기 ì „êµ¬ ì•½ë¬¼ì€ ì‚¬ì´í´ë¡œí¬ìŠ¤íŒŒë¯¸ë“œ 단ë…ì˜ íˆ¬ì—¬ì— ëŒ€í•œ ì •ìƒìƒíƒœë³´ë‹¤ ë” ê¸´ 지ì†ê¸°ê°„ì„ ìœ„í•´ ì´ëŸ¬í•œ 복용량 ë˜ëŠ” ë” ë‚®ì€ ë³µìš©ëŸ‰ì—ì„œ 투여ë˜ëŠ” 사ì´í´ë¡œí¬ìŠ¤íŒŒë¯¸ë“œì™€ 함께 병용투여ëœë‹¤.
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í•œ 구체예ì—ì„œ, 본 ë°œëª…ì€ ìƒì‘하는 ì‹ ê·œí•œ ë˜ëŠ” ê³µì§€ëœ í¬ìŠ¤í¬ë¼ë¯¸ë°ì´íŠ¸ 알킬화기를 방출하는 ìƒì²´ 환ì›ì—ì„œ ì‹ ê·œì˜ í¬ìŠ¤í¬ë¼ë¯¸ë°ì´íŠ¸ 알킬화기 ì „êµ¬ 약물 ë° ê·¸ë“¤ì˜ ì´ì˜¨í™” 형태를 ì œê³µí•œë‹¤:
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다른 구체예ì—ì„œ, 본 ë°œëª…ì€ ì˜¥ì‹¬-í¬ìŠ¤í¬ë¼ë¯¸ë°ì´íŠ¸ 알킬화기 컨쥬게ì´íŠ¸ë¥¼ ì œê³µí•œë‹¤:
투여ë˜ëŠ” í¬ìŠ¤í¬ë¼ë¯¸ë°ì´íŠ¸ 알킬화기 ì „êµ¬ ì•½ë¬¼ì˜ ì–‘, ë° ë”°ë¼ì„œ 투여ë˜ëŠ” ë³µìš©ëŸ‰ì— í¬í•¨ë˜ëŠ” í¬ìŠ¤í¬ë¼ë¯¸ë°ì´íŠ¸ 알킬화기 ì „êµ¬ 약물 ë° ìƒê¸° ë³µìš©ëŸ‰ì„ í¬í•¨í•˜ëŠ” ì œí’ˆì˜ ì–‘ì€ ì¹˜ë£Œë˜ëŠ” 개체, ì•”ì˜ ê²½ì¤‘ë„, ì•”ì˜ ë¶€ìœ„, íˆ¬ì—¬ì˜ ì†ë„, ì „êµ¬ ì•½ë¬¼ì˜ ì†Œì¸(예를 들어, 분ìžëŸ‰, ìš©í•´ë„ ë° ì €ì‚°ì†Œ ë° ì •ìƒì‚°ì†Œ 세í¬ë…성), í¬ìŠ¤í¬ë¼ë¯¸ë°ì´íŠ¸ 알킬화기 ì „êµ¬ ì•½ë¬¼ì— click here ì˜í•´ 방출ë˜ëŠ” 세í¬ë…ì„±ì œ, ë° ì²˜ë°©í•˜ëŠ” ì˜ì‚¬ì˜ íŒë‹¨ì— ì˜ì¡´í• 것ì´ë‹¤.
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